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RNAi Experiment: Simmer:ZK858.4:Screen_A Ace View of Simmer:ZK858.4:Screen_A
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  ZK858.4 (mel-26)
Description of "ZK858.4"  mel-26 encodes a MATH and BTB/POZ domain-containing protein that functions as a novel substrate-specific adaptor of the CUL-3-containing E3 ubiquitin ligase; MEL-26 is required maternally for formation of mitotic spindles in the early embryo, and as a component of a ubiquitin ligase complex, for degradation of the microtubule-severing protein MEI-1 at the meiosis to mitosis transition; MEL-26 is also required maternally for embryonic morphogenesis; since MEL-26 contains a meprin-associated Traf homology (MATH) domain, it might be involved in apoptosis.
KOG Annotation  Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:9133874..9135173)
Transcript overlap: 592 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 508
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "ZK858.4" Links  Wormbase NCBI
Simmer:ZK858.4:Screen_A Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 90 %
Adult  Dpy
Simmer:ZK858.4:Screen_A Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_ZK858.4 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of ZK858.4 Browse using GBrowse
Gene Graph