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RNAi Experiment: TH:300D8 Ace View of TH:300D8
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F35G12.3 (sel-5)
Description of "F35G12.3"  sel-5 encodes a serine/threonine kinase most similar to mammalian GAK1 and Saccharomyces cerevisiae Pak1p; SEL-5 is required for LIN-12/Notch-mediated signaling events that instruct cells of equivalent developmental potential to adopt distinct fates; sel-5 encodes two protein kinase isoforms generated from alternatively spliced mRNAs and appears to influence cell fate decisions by acting before or during ligand-dependent release of the LIN-12 intracellular domain.
KOG Annotation  ARK protein kinase family
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:4575686..4577973)
Transcript overlap: 1462 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 1295
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F35G12.3" Links  Wormbase NCBI
TH:300D8 Phenotypes Help with Phenotypes
Phenotype  WTDIC phenotype -- Embryonic development normal
TH:300D8 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  TH:300D8 (PCR_reagent)
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Delivery Method  Injection
Date  2000-11-16
Gene Plot of F35G12.3 Browse using GBrowse
Gene Graph