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RNAi Experiment: TH:300H2 Ace View of TH:300H2
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  R74.3 (xbp-1)
Description of "R74.3"  xbp-1 encodes a bZIP transcription factor orthologous to yeast Hac1 and mammalian X box-binding protein 1 (XBP-1, OMIM:194355); XBP-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); XBP-1 mRNA is spliced by the IRE-1 endoribonuclease to promote translation of transcriptionally active XBP-1 that positively regulates UPR gene expression to maintain ER homeostasis and promote normal development.
KOG Annotation  Transcription factor XBP-1
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:4193737..4194733)
Transcript overlap: 834 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 792
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "R74.3" Links  Wormbase NCBI
TH:300H2 Phenotypes Help with Phenotypes
Phenotype  WTDIC phenotype -- Embryonic development normal
TH:300H2 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  TH:300H2 (PCR_reagent)
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Delivery Method  Injection
Date  2000-11-16
Gene Plot of R74.3 Browse using GBrowse
Gene Graph