RNAi Experiment: TH:300H2 |
Ace View of TH:300H2
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Genes Inhibited |
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Gene Inhibited |
R74.3 (xbp-1) |
Description of "R74.3" |
xbp-1 encodes a bZIP transcription factor orthologous to yeast Hac1 and mammalian X box-binding protein 1 (XBP-1, OMIM:194355); XBP-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); XBP-1 mRNA is spliced by the IRE-1 endoribonuclease to promote translation of transcriptionally active XBP-1 that positively regulates UPR gene expression to maintain ER homeostasis and promote normal development. |
KOG Annotation  |
Transcription factor XBP-1
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (III:4193737..4194733)
Transcript overlap: 834 nt |
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Sliding Window |
Raw score: 792
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "R74.3" Links |
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TH:300H2 Phenotypes |
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Phenotype |
WTDIC phenotype -- Embryonic development normal
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TH:300H2 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
TH:300H2 (PCR_reagent) |
Reference |
Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." |
Delivery Method |
Injection |
Date |
2000-11-16 |
Gene Plot of R74.3 |
Browse using GBrowse
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