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RNAi Experiment: TH:304A8 Ace View of TH:304A8
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C05D11.6 (nas-4)
Description of "C05D11.6"  nas-4 encodes a predicted extracellular matrix metalloprotease of the M12A (astacin) family that contains an N-terminal signal sequence and a catalytic domain, but no recognizable regulatory domains in the C-terminus; as loss of nas-4 activity via RNAi results in no obvious abnormalities, the precise role of NAS-4 in C. elegans development and/or behavior is not yet known; however, an NAS-4 translational reporter is expressed in the pharynx and intestine in larvae and adults, suggesting a role for NAS-4 in digestion; NAS-4 is specifically detected within cells of the pharyngeal procorpus, metacorpus, isthmus, and terminal bulb, with extracellular expression detected in the lumen of the terminal bulb and in the gut.
KOG Annotation  Meprin A metalloprotease
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:6412559..6414477)
Transcript overlap: 1004 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 859
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C05D11.6" Links  Wormbase NCBI
TH:304A8 Phenotypes Help with Phenotypes
Phenotype  WTDIC phenotype -- Embryonic development normal
TH:304A8 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  TH:304A8 (PCR_reagent)
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Delivery Method  Injection
Date  2000-11-16
Gene Plot of C05D11.6 Browse using GBrowse
Gene Graph