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RNAi Experiment: TH:306H8 Ace View of TH:306H8
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F54E7.7 (rcn-1)
Description of "F54E7.7"  rcn-1 encodes a calcipressin, which binds and inhibits calcineurin; RCN-1's orthologs include yeast Rcn1p and human DSCR1 (OMIM:602917; overexpressed in Down syndrome and Alzheimer disease); rcn-1 is expressed in hypodermal seam cells, various neurons, vulval epithelial and muscle cells, marginal pharyngeal cells, and in the male tail; rcn-1 transcription is regulated by TAX-6, and RCN-1 binds TAX-6 protein if free Ca[2+] is present; RCN-1 overexpression, like calcineurin deficiency, causes defects in body size, cuticle thickness, fertility, growth rate, and serotonin-resistance in egg-laying.
KOG Annotation  Calcineurin-mediated signaling pathway inhibitor DSCR1
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:5682399..5684175)
Transcript overlap: 881 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 776
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F54E7.7" Links  Wormbase NCBI
TH:306H8 Phenotypes Help with Phenotypes
Phenotype  WTDIC phenotype -- Embryonic development normal
TH:306H8 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  TH:306H8 (PCR_reagent)
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Delivery Method  Injection
Date  2000-11-16
Gene Plot of F54E7.7 Browse using GBrowse
Gene Graph