RNAi Experiment: TH:310A1 |
Ace View of TH:310A1
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Genes Inhibited |
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Gene Inhibited |
F10E9.6 (mig-10) |
Description of "F10E9.6" |
mig-10 encodes a protein containing a pleckstrin homology domain and a proline-rich region, and is similar to the SH2-domain containing adapter proteins Grb7 and Grb10 which are involved in receptor tyrosine kinase-mediated signal transduction; MIG-10 is likely required for signal transduction during cell migration, as it is required non-cell autonomously for excretory canal development and anterior-posterior migrations of the embryonic neurons ALM, CAN, and HSN; mig-10 mutations appear to interact genetically with mutations in all three C. elegans rac genes, ced-10, mig-2, and rac-2, suggesting partial redundancy during neuronal migration and excretory canal outgrowth; MIG-10 is expressed in many embryonic cells and in four cells in the adult head. |
KOG Annotation  |
Growth factor receptor-bound proteins (GRB7, GRB10, GRB14)
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (III:8280701..8282806)
Transcript overlap: 250 nt |
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Sliding Window |
Raw score: 229
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "F10E9.6" Links |
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TH:310A1 Phenotypes |
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Phenotype |
WTDIC phenotype -- Embryonic development normal
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TH:310A1 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
TH:310A1 (PCR_reagent) |
Reference |
Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." |
Delivery Method |
Injection |
Date |
2000-11-16 |
Gene Plot of F10E9.6 |
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