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RNAi Experiment: TH:312C5 Ace View of TH:312C5
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F56D2.4 (uev-2)
Description of "F56D2.4"  uev-2 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the characteristic UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; as loss of UEV-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UEV-2 in C. elegans development and/or behavior is not yet known; based on similarity to Saccharomyces cerevisiae and human proteins, however, UEV-2 may play a role in cell cycle control or response to stress or DNA damage.
KOG Annotation  Ubiquitin-protein ligase
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:5583205..5584376)
Transcript overlap: 582 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 477
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F56D2.4" Links  Wormbase NCBI
TH:312C5 Phenotypes Help with Phenotypes
Phenotype  WTDIC phenotype -- Embryonic development normal
TH:312C5 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  TH:312C5 (PCR_reagent)
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Delivery Method  Injection
Date  2000-11-16
Gene Plot of F56D2.4 Browse using GBrowse
Gene Graph