RNAi Experiment: TH:312D5 |
Ace View of TH:312D5
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Genes Inhibited |
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Gene Inhibited |
C05D2.5 (gak-1) |
Description of "C05D2.5" |
gak-1 encodes a protein that contains an AT hook motif, a DNA-binding domain that shows a preference for binding stretches of A/T base pairs; GAK-1 appears to play a role in meiotic chromosome segregation, as overexpression results in post-prophase I chromosome segregation abnormalities, and a corresponding increase in embryonic lethality and the proportion of genotypically XO males in an otherwise self-fertile, XX hermaphrodite population; loss of gak-1 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodites, suggesting a possible role in germline development as well; gak-1 expression is enhanced in the germline, although its precise subcellular localization has not been reported. |
Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (III:5604796..5606973)
Transcript overlap: 1455 nt |
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Sliding Window |
Raw score: 1329
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "C05D2.5" Links |
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TH:312D5 Phenotypes |
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Phenotype |
WTDIC phenotype -- Embryonic development normal
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TH:312D5 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
TH:312D5 (PCR_reagent) |
Reference |
Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." |
Delivery Method |
Injection |
Date |
2000-11-16 |
Gene Plot of C05D2.5 |
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