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RNAi Experiment: TH:314d3 Ace View of TH:314d3
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C23G10.4 (rpn-2)
Description of "C23G10.4"  rpn-2 encodes a non-ATPase subunit of the 26S proteasome's 19S regulatory paritcle (RP) base subcomplex; RPN-2 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding and recognition of protein substrates and/or recycling of ubiquitin moieties during protein degradation; RPN-2 is expressed sporadically at all stages of development in the pharynx, intestine, body wall muscle, somatic gonad, neurons, and hypodermis.
KOG Annotation  26S proteasome regulatory complex, subunit RPN2/PSMD1
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:6199364..6201037)
Transcript overlap: 1578 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 1515
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C23G10.4" Links  Wormbase NCBI
TH:314d3 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
TH:314d3 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  TH:314d3 (PCR_reagent)
Remark  Phenotype comment -- Confirmed with independent dsRNA (C23G10.4-RNA2; similar DIC phenotype, but progeny test was not embryonic lethal).
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Date  2000-11-16
Gene Plot of C23G10.4 Browse using GBrowse
Gene Graph