RNAi Experiment: TH:320d1 |
Ace View of TH:320d1
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Genes Inhibited |
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Gene Inhibited |
F56A8.3 |
KOG Annotation  |
Leucine-rich repeat protein
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (III:13256129..13257196)
Transcript overlap: 602 nt |
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External "F56A8.3" Links |
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Gene Inhibited |
B0464.5 (spk-1) |
Description of "B0464.5" |
spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600). |
KOG Annotation  |
Serine/threonine protein kinase
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Evidence for Inhibition |
Sliding Window |
Raw score: 1478
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "B0464.5" Links |
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TH:320d1 Phenotypes |
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Embryonic |
Emb Penetrance None reported |
TH:320d1 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
TH:320d1 (PCR_reagent) |
Remark |
Phenotype comment -- Confirmed in part with independent dsRNA (B0464.5-RNA2; weaker DIC phenotype: cleavage furrow ingresses with a delay; excess cortical contractions, little rocking during anaphase, failure in P1 rotation; only partial embryonic lethal). |
Reference |
Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." |
Date |
2000-11-16 |
Gene Plot of F56A8.3 |
Browse using GBrowse
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Gene Plot of B0464.5 |
Browse using GBrowse
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