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RNAi Experiment: TH:320e11 Ace View of TH:320e11
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  K01G5.7 (tbb-1)
Description of "K01G5.7"  This gene encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-1 is redundant for embryonic viability, due to its paralog TBB-2.
KOG Annotation  Beta tubulin
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:10741321..10742370)
Transcript overlap: 962 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 920
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "K01G5.7" Links  Wormbase NCBI
TH:320e11 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
TH:320e11 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  TH:320e11 (PCR_reagent)
Remark  Phenotype comment -- Confirmed with independent dsRNA (K01G5.7-RNA2; similar phenotype). Phenotype could potentially be due to cross-RNAi inhibition of other tubulin genes (see BLASTN results). We note, however, that RNAi directed specifically against one other tubulin gene on chromosome III (C54C6.2; ben-1) failed to give rise to a phenotype, suggesting that the phenotype noted here may truly reflect a requirement for K01G5.7 function.
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Date  2000-11-16
Gene Plot of K01G5.7 Browse using GBrowse
Gene Graph