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RNAi Experiment: TH:321F12 Ace View of TH:321F12
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  ZK632.6 (cnx-1)
Description of "ZK632.6"  cnx-1 encodes the C. elegans ortholog of calnexin, a transmembrane calcium-binding protein that localizes to the endoplasmic reticulum; by homology, CNX-1 is predicted to function as a molecular chaperone that is required for glycoprotein folding and maturation as well as for regulation of intracellular calcium homeostasis; although loss of cnx-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, genetic studies indicate that cnx-1 RNAi can suppress the necrotic-like cell death induced by hyperactive mutations in the MEC-4 and DEG-1 ion channels; thus, in addition to its proposed role in glycoprotein processing, CNX-1 is also required for necrotic-like neuronal death.
KOG Annotation  Calnexin
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:9815274..9816467)
Transcript overlap: 820 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 717
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "ZK632.6" Links  Wormbase NCBI
TH:321F12 Phenotypes Help with Phenotypes
Phenotype  WTDIC phenotype -- Embryonic development normal
TH:321F12 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  TH:321F12 (PCR_reagent)
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Delivery Method  Injection
Date  2000-11-16
Gene Plot of ZK632.6 Browse using GBrowse
Gene Graph