RNAi Experiment: TH:325G3 |
Ace View of TH:325G3
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Genes Inhibited |
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Gene Inhibited |
Y47D3B.7 (sbp-1) |
Description of "Y47D3B.7" |
sbp-1 encodes a basic helix-loop-helix (bHLH) transcription factor homologous to the mammalian Sterol Regulatory Element Binding Proteins (SREBPs, OMIM:184756, overexpression of nuclear form of SREBP-1c is associated with insulin resistance and features of congenital generalized lipodystrophy); in C. elegans, SBP-1 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for embryonic and larval development; sbp-1 expression is detected exclusively in the intestine, the major site of fat storage, from early embryogenesis through adulthood. |
KOG Annotation  |
Predicted DNA-binding protein
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (III:11436958..11438642)
Transcript overlap: 1226 nt |
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Sliding Window |
Raw score: 1134
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.901 |
Wormbase (BLAST) |
RNAi primary |
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External "Y47D3B.7" Links |
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Gene Inhibited |
Y49F6C.6 |
Evidence for Inhibition |
Sliding Window |
Raw score: 125
Relative score: 0.11 (Best raw score= for Gene )
Specificity index: 0.099 |
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External "Y49F6C.6" Links |
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TH:325G3 Phenotypes |
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Larval |
Gro
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Adult |
Bmd
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TH:325G3 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
TH:325G3 (PCR_reagent) |
Remark |
Phenotype comment -- Phenotype confirmed by second independent RNA (RNA2). |
Reference |
Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." |
Date |
2000-11-16 |
Gene Plot of Y47D3B.7 |
Browse using GBrowse
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Gene Plot of Y49F6C.6 |
Browse using GBrowse
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