RNAi Experiment: TH:329C6 |
Ace View of TH:329C6
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Genes Inhibited |
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Gene Inhibited |
B0336.8 (lgg-3) |
Description of "B0336.8" |
lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities. |
KOG Annotation  |
Protein conjugation factor involved in autophagy
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (III:5697193..5698334)
Transcript overlap: 357 nt |
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Sliding Window |
Raw score: 294
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "B0336.8" Links |
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Gene Inhibited |
B0336.7 |
Description of "B0336.7" |
Associated GO Term : nucleic acid binding |
Evidence for Inhibition |
ePCR |
Transcript overlap: 73 nt |
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Wormbase (BLAST) |
RNAi primary |
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External "B0336.7" Links |
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TH:329C6 Phenotypes |
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Phenotype |
WTDIC phenotype -- Embryonic development normal
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TH:329C6 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
TH:329C6 (PCR_reagent) |
Reference |
Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." |
Delivery Method |
Injection |
Date |
2000-11-16 |
Gene Plot of B0336.8 |
Browse using GBrowse
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Gene Plot of B0336.7 |
Browse using GBrowse
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