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RNAi Experiment: TH:329F9 Ace View of TH:329F9
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  T07C4.4 (spp-1)
Description of "T07C4.4"  spp-1 encodes a predicted transmembrane protein containing a saposin (B) domain that is a member of a saposin-like protein superfamily containing mammalian NK-lysin and granulysin and the protozoan amoebapores; SPP-1 is predicted to function as a lipid-binding protein with cytotoxic, pore-forming activity, and in vitro, does exhibit antibacterial activity; loss of SPP-1 function via RNA-mediated interference (RNAi) does not, however, result in any abnormalities.
Evidence for Inhibition 
ePCR Status: Best_ePCR (III:10354828..10355761)
Transcript overlap: 498 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 456
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.687
Wormbase (BLAST) RNAi primary
External "T07C4.4" Links  Wormbase NCBI
Gene Inhibited  T07C4.1
Description of "T07C4.1"  T07C4.1 is orthologous to the human gene URIDINE MONOPHOSPHATE SYNTHETASE (OROTATE PHOSPHORIBOSYL TRANSFERASE AND OROTIDINE-5'-DECARBOXYLASE) (UMPS; OMIM:258900), which when mutated leads to disease.
KOG Annotation  Uridine 5'- monophosphate synthase/orotate phosphoribosyltransferase
What's a KOG?
Evidence for Inhibition 
ePCR Transcript overlap: 77 nt Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 77
Relative score: 0.169 (Best raw score= for Gene )
Specificity index: 0.116
External "T07C4.1" Links  Wormbase NCBI
Gene Inhibited  T07C4.3
Evidence for Inhibition 
ePCR Status: Bottom50_percentile_ePCR (III:10354828..10355761)
Transcript overlap: 152 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 131
Relative score: 0.287 (Best raw score= for Gene )
Specificity index: 0.197
External "T07C4.3" Links  Wormbase NCBI
TH:329F9 Phenotypes Help with Phenotypes
Phenotype  WTDIC phenotype -- Embryonic development normal
TH:329F9 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  TH:329F9 (PCR_reagent)
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Delivery Method  Injection
Date  2000-11-16
Gene Plot of T07C4.1 Browse using GBrowse
Gene Graph
Gene Plot of T07C4.4 Browse using GBrowse
Gene Graph
Gene Plot of T07C4.3 Browse using GBrowse
Gene Graph