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RNAi Experiment: TH:335A4 Ace View of TH:335A4
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  K08E3.6 (cyk-4)
Description of "K08E3.6"  cyk-4 encodes a GTPase activating protein (GAP) for the Rho family of GTPases that, together with ZEN-4, is sufficient to promote the formation of the large bundles of microtubules that form the central spindle during anaphase, and is required for fertility and coordinated locomotion postembryonically; localizes to the central spindle during anaphase interdependently with ZEN-4, and interacts with ZEN-4 in vitro and in vivo.
KOG Annotation  GTPase-activating protein
What's a KOG?
Evidence for Inhibition 
ePCR Status: Best_ePCR (III:13770398..13771253)
Transcript overlap: 248 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 185
Relative score: 0.911 (Best raw score= for Gene )
Specificity index: 0.477
Wormbase (BLAST) RNAi primary
External "K08E3.6" Links  Wormbase NCBI
Gene Inhibited  K08E3.7 (pdr-1)
Description of "K08E3.7"  pdr-1 encodes an ortholog of human parkin (PARK2; OMIM:602544), which when mutated leads to the juvenile 2 form of Parkinson disease (OMIM:600116).
KOG Annotation  E3 ubiquitin-protein ligase (Parkin protein)
What's a KOG?
Evidence for Inhibition 
ePCR Status: Top85_percentile_ePCR (III:13770398..13771253)
Transcript overlap: 245 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 203
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.523
Wormbase (BLAST) RNAi primary
External "K08E3.7" Links  Wormbase NCBI
TH:335A4 Phenotypes Help with Phenotypes
Phenotype  WTDIC phenotype -- Embryonic development normal
TH:335A4 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  TH:335A4 (PCR_reagent)
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Delivery Method  Injection
Date  2000-11-16
Gene Plot of K08E3.6 Browse using GBrowse
Gene Graph
Gene Plot of K08E3.7 Browse using GBrowse
Gene Graph