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RNAi Experiment: TH:338a7 Ace View of TH:338a7
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  Y43F4B.6 (klp-19)
Description of "Y43F4B.6"  klp-19 encodes a plus-end-directed microtubule motor protein that is most closely related to motors of the kinesin-4 family; KLP-19 activity is essential for embryonic and larval development and is required for generating a force that aligns sister chromatid kinetochores directly opposite the spindle poles thus ensuring proper holocentric chromosome segregation; KLP-19 expression is detected in embryos and in the gonad, where it is most strongly expressed in distal mitotic nuclei and in late meiotic prophase nucleoplasm; during meiosis and mitosis, KLP-19 expression is dynamic and is detected in the nucleoplasm, the spindle body, in association with condensed chromosomes (particularly between homologous chromosomes), and in the spindle interzone.
KOG Annotation  Kinesin-like protein
What's a KOG?
Evidence for Inhibition 
ePCR Status: Best_ePCR (III:13301818..13303378)
Transcript overlap: 730 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 688
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.662
Wormbase (BLAST) RNAi primary
External "Y43F4B.6" Links  Wormbase NCBI
Gene Inhibited  Y43F4B.5
Description of "Y43F4B.5"  Associated GO Term : intramolecular transferase activity, phosphotransferases
Evidence for Inhibition 
ePCR Status: Top50_percentile_ePCR (III:13301818..13303378)
Transcript overlap: 459 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 438
Relative score: 0.512 (Best raw score= for Gene )
Specificity index: 0.338
Wormbase (BLAST) RNAi primary
External "Y43F4B.5" Links  Wormbase NCBI
TH:338a7 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
TH:338a7 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  TH:338a7 (PCR_reagent)
Remark  Phenotype comment -- Confirmed with independent dsRNA (Y43F4B.6-RNA2; similar -albeit seemingly weaker- phenotype).
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Date  2000-11-16
Gene Plot of Y43F4B.5 Browse using GBrowse
Gene Graph
Gene Plot of Y43F4B.6 Browse using GBrowse
Gene Graph