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RNAi Experiment: TH:340H4 Ace View of TH:340H4
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  T20B12.2 (tbp-1)
Description of "T20B12.2"  tbp-1 encodes the C. elegans ortholog of the human TATA-box-binding protein (TBP; OMIM:600075; mutated in spinocerebellar ataxia 17); consistent with its proposed role in transcriptional regulation, TBP-1 has been shown to provide TFIID-like basal transcription activity in human and C. elegans extracts, to bind specifically to a TATA box sequence, and to interact with TFIIA and TFIIB transcription factors from other species; large-scale RNA-mediated interference (RNAi) screens indicate that tbp-1 activity is required for embryonic and larval development, as well as for normal rates of postembryonic growth.
KOG Annotation  TATA-box binding protein (TBP), component of TFIID and TFIIIB
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:7384810..7385566)
Transcript overlap: 705 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 663
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "T20B12.2" Links  Wormbase NCBI
TH:340H4 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
TH:340H4 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  TH:340H4 (PCR_reagent)
Remark  Phenotype comment -- A second independent RNA (RNA2) yielded a weaker phenotype (early larval arrest).
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Date  2000-11-16
Gene Plot of T20B12.2 Browse using GBrowse
Gene Graph