RNAi Experiment: TH:340H4 |
Ace View of TH:340H4
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Genes Inhibited |
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Gene Inhibited |
T20B12.2 (tbp-1) |
Description of "T20B12.2" |
tbp-1 encodes the C. elegans ortholog of the human TATA-box-binding protein (TBP; OMIM:600075; mutated in spinocerebellar ataxia 17); consistent with its proposed role in transcriptional regulation, TBP-1 has been shown to provide TFIID-like basal transcription activity in human and C. elegans extracts, to bind specifically to a TATA box sequence, and to interact with TFIIA and TFIIB transcription factors from other species; large-scale RNA-mediated interference (RNAi) screens indicate that tbp-1 activity is required for embryonic and larval development, as well as for normal rates of postembryonic growth. |
KOG Annotation  |
TATA-box binding protein (TBP), component of TFIID and TFIIIB
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (III:7384810..7385566)
Transcript overlap: 705 nt |
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Sliding Window |
Raw score: 663
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "T20B12.2" Links |
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TH:340H4 Phenotypes |
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Embryonic |
Emb Penetrance None reported |
TH:340H4 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
TH:340H4 (PCR_reagent) |
Remark |
Phenotype comment -- A second independent RNA (RNA2) yielded a weaker phenotype (early larval arrest). |
Reference |
Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." |
Date |
2000-11-16 |
Gene Plot of T20B12.2 |
Browse using GBrowse
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