RNAi Experiment: TH:340h12 |
Ace View of TH:340h12
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Genes Inhibited |
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Gene Inhibited |
C05D11.3 |
Description of "C05D11.3" |
C05D11.3 encodes an ortholog of APACD (ATP binding protein associated with cell differentiation) conserved in eukaryotes; C05D11.3 has a thioredoxin-like domain, probably lacking catalytic activity; mouse APACD is both cytoplasmic and nuclear, often localized to centrosomes and midbody; C05D11.3 is expressed in all developmental stages, preferentially in neurons and vulva; C05D11.3 is required for normal mitotic spindle formation, pronuclear migration and nuclear-centrosome rotation. |
KOG Annotation  |
ATP binding protein
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (III:6432121..6432587)
Transcript overlap: 424 nt |
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Sliding Window |
Raw score: 382
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "C05D11.3" Links |
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TH:340h12 Phenotypes |
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Embryonic |
Emb Penetrance None reported |
TH:340h12 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
TH:340h12 (PCR_reagent) |
Remark |
Phenotype comment -- Confirmed with independent dsRNA (C05D11.3-RNA2; similar DIC phenotype, but progeny test was not embryonic lethal). |
Reference |
Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." |
Date |
2000-11-16 |
Gene Plot of C05D11.3 |
Browse using GBrowse
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