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RNAi Experiment: TH:340h12 Ace View of TH:340h12
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C05D11.3
Description of "C05D11.3"  C05D11.3 encodes an ortholog of APACD (ATP binding protein associated with cell differentiation) conserved in eukaryotes; C05D11.3 has a thioredoxin-like domain, probably lacking catalytic activity; mouse APACD is both cytoplasmic and nuclear, often localized to centrosomes and midbody; C05D11.3 is expressed in all developmental stages, preferentially in neurons and vulva; C05D11.3 is required for normal mitotic spindle formation, pronuclear migration and nuclear-centrosome rotation.
KOG Annotation  ATP binding protein
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:6432121..6432587)
Transcript overlap: 424 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 382
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C05D11.3" Links  Wormbase NCBI
TH:340h12 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
TH:340h12 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  TH:340h12 (PCR_reagent)
Remark  Phenotype comment -- Confirmed with independent dsRNA (C05D11.3-RNA2; similar DIC phenotype, but progeny test was not embryonic lethal).
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Date  2000-11-16
Gene Plot of C05D11.3 Browse using GBrowse
Gene Graph