| RNAi Experiment: TH:341b7 |
Ace View of TH:341b7
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| Genes Inhibited |
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| Gene Inhibited |
H04J21.3 (gip-1) |
| Description of "H04J21.3" |
gip-1 encodes the C. elegans homolog of Saccharomyces cerevisiae Spc98p, a gamma-tubulin-binding protein that with Spc97p forms part of a gamma-tubulin ring complex that can nucleate microtubule formation in vitro and in vivo; in C. elegans, GIP-1 is essential for embryogenesis and required for formation of centrosomal asters during interphase and formation of the mitotic spindle, but not for formation of mitotic asters; GIP-1 colocalizes with TBG-1/gamma-tubulin to centrosomes during interphase and mitosis; GIP-1 and TBG-1 are required reciprocally for centrosomal localization. |
| Evidence for Inhibition |
| ePCR |
Status: Unique_ePCR (III:2358588..2359734)
Transcript overlap: 426 nt |
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| Sliding Window |
Raw score: 384
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
| Wormbase (BLAST) |
RNAi primary |
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| External "H04J21.3" Links |
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| TH:341b7 Phenotypes |
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| Embryonic |
Emb Penetrance None reported |
| TH:341b7 Experiment Details |
Ace View |
| Laboratory |
TH |
| RNAi Reagent & Type |
TH:341b7 (PCR_reagent) |
| Remark |
Phenotype comment -- Confirmed with independent dsRNA (C23G10.4-RNA2; similar DIC phenotype, but progeny test was not embryonic lethal). |
| Reference |
Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." |
| Date |
2000-11-16 |
| Gene Plot of H04J21.3 |
Browse using GBrowse
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