Ace View of TH:343A2 | ||||||
Gene Inhibited | Y49E10.1 (rpt-6) | |||||
Description of "Y49E10.1" | rpt-6 encodes a triple A ATPase that is a subunit of the 26S proteasome 19S regulatory particle (RP) base subcomplex; RPT-6 is required for embryonic and larval development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome. | |||||
KOG Annotation  | 26S proteasome regulatory complex, ATPase RPT6 |
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Evidence for Inhibition |
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External "Y49E10.1" Links | ||||||
Gene Inhibited | K10G4.7 (srh-262) | |||||
Evidence for Inhibition |
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External "K10G4.7" Links | ||||||
Embryonic | Emb Penetrance None reported | |||||
Laboratory | TH | |||||
RNAi Reagent & Type | TH:343A2 (PCR_reagent) | |||||
Remark | Phenotype comment -- Confirmed with independent dsRNA (Y49E10.1-RNA2; less penetrant DIC phenotype); not confirmed with third dsRNA (Y49E10.1-RNA3). | |||||
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." | |||||
Date | 2000-11-16 | |||||
Gene Plot of Y49E10.1 | ||||||
Gene Plot of K10G4.7 | ||||||