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RNAi Experiment: WBRNAi00038529 Ace View of WBRNAi00038529
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C52B9.7 (paf-2)
Description of "C52B9.7"  paf-2 encodes a homolog of vertebrate Type II Platelet-activating factor-acetylhydrolase (PAF-AH) that is 70% identical to PAF-2 that is required for embryogenesis and affects organization of the hypodermis.
Evidence for Inhibition 
Sliding Window Raw score: 1047
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C52B9.7" Links  Wormbase NCBI
WBRNAi00038529 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Larval  Lvl
WBRNAi00038529 Experiment Details Ace View
RNAi Reagent & Type  AF386745 (cDNA_reagent)
Remark  Most embryos that were arrested during embryogenesis had a very lumpy morphology or were ruptured, with internal cells oozing through the holes in the epidermis. In some embryos, no MH27 staining was seen in the anterior part of the embryo, whereas the posterior part was enclosed by epidermal cells and elongated partially, which is indicative of anterior rupture during enclosure. Hatched but arrested paf-2 RNAi animals also exhibited morphology defects, including ectopic protuberances and a kinked tail.
Reference  Inoue T et al. (2004) Proceedings of the National Academy of Sciences USA "Type II platelet-activating factor-acetylhydrolase is essential for ...."
Delivery Method  Transgene_expression
Date  2004-9-07
Gene Plot of C52B9.7 Browse using GBrowse
Gene Graph