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RNAi Experiment: WBRNAi00038539 Ace View of WBRNAi00038539
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F11C1.6 (nhr-25)
Description of "F11C1.6"  nhr-25 encodes a nuclear hormone receptor orthologous to Drosophila Ftz-F1; NHR-25 is required for embryogenesis, molting, vulval and gonadal development, and hypodermal expression of acn-1; nhr-25 is expressed in gonads and loaded into embryos as a maternal transcript; nhr-25 is zygotically expressed in progeny of the E cell, and then in hypodermis and gut; the role of NHR-25 in molting may be evolutionarily conserved between nematodes and arthopods.
Evidence for Inhibition 
Sliding Window Raw score: 668
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F11C1.6" Links  Wormbase NCBI
WBRNAi00038539 Phenotypes Help with Phenotypes
Larval  Mlt n=191
Adult  Egl n=143
Phenotype  Morphology defect Animals expressing the pcol-10::nhr-25 sense and antisense constructs in sid-1(qt-2) background sometimes had a shorter body length and were more severely defective in the posterior end.
WBRNAi00038539 Experiment Details Ace View
Laboratory  MH
RNAi Reagent & Type  probe_1:F11C1 (Unknown_reagent_type)
Remark  For tissue-specific RNAi, the first 0.9 kb of nhr-25 coding sequence was fused in the sense and antisense orientations to the col-10 promoter, which is expressed in epidermal cells during embryonic and larval stages. Both constructs were injected at 50 ng/mkl, and a sur-5::gfp transcriptional fusion construct was used as a coinjection marker.
Reference  Chen Z et al. (2004) Molecular and Cellular Biology "The Caenorhabditis elegans nuclear receptor gene nhr-25 regulates epidermal ...."
Delivery Method  Transgene_expression
Date  2004-9-01
Gene Plot of F11C1.6 Browse using GBrowse
Gene Graph