Ace View of WBRNAi00038551 | |||
Gene Inhibited | B0041.7 (xnp-1) | ||
Description of "B0041.7" | xnp-1 encodes an ATP-dependent DNA helicase of the SNF2 family that is orthologous to human XNP/ATR-X, which is associated with a number of X-linked mental retardation syndromes; in C. elegans, xnp-1 activity is required at high temperatures for embryogenesis, somatic gonad development, fertility, vulval morphogenesis, and meiotic X chromosome segregation; in addition, animals doubly mutant for xnp-1 and lin-35/Rb, hpl-2/HP1, or nucleosome remodelling and histone deacetylase (NuRD) complex members such as lin-53 and let-418, display larval arrest with growth cessation but continued cell proliferation; xnp-1 is also required, with lin-35/Rb and hpl-2/HP1, for proper regulation of transgene expression; xnp-1 mRNA, detectable in embryos and the germline by in situ hybridization, is expressed at highest levels in embryos with decreasing levels seen in successive larval stages; xnp-1 transcriptional reporter fusions exhibit strong expression beginning at mid-embryogenesis but fading by embryonic morphogenesis; at hatching, expression is observed in all dividing cells including the P lineage, and at later larval stages expression is observed in the vulval precursor cells. | ||
KOG Annotation  | Transcription regulator XNP/ATRX, DEAD-box superfamily |
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Evidence for Inhibition | |||
External "B0041.7" Links | |||
Adult | Gon
n=44 Ste n=10 |
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Laboratory | WY | ||
RNAi Reagent & Type | WBPaper00024322:B0041_1.1 (PCR_reagent) | ||
Remark | brood size = 8 +- 10 (n = 8) | ||
Reference | Bender AM et al. (2004) Developmental Biology "lin-35/Rb and xnp-1/ATR-X function redundantly to control somatic gonad ...." | ||
Delivery Method | Injection | ||
Date | 2004-7-24 | ||
Gene Plot of B0041.7 | |||