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RNAi Experiment: WBRNAi00038575 Ace View of WBRNAi00038575
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  Y73C8B.4 (lag-2)
Description of "Y73C8B.4"  lag-2 encodes a transmembrane protein of the Delta/Serrate/Lag-2 (DSL) family that functions as a signaling ligand for the GLP-1 and LIN-12 Notch-like receptors; LAG-2 is required for larval viability and for cell fate decisions involving the germline (meiosis vs mitosis), the somatic gonad, and the early embryo; in addition, LAG-2 functions redundantly with the transmembrane APX-1 and secreted DSL-1 ligands to regulate lateral signaling during vulval development; LAG-2 is expressed in the distal tip cell of the somatic gonad, the ventral nerve cord, the descendants of ABalap and MSap in the developing embryo, and in all six vulval precursor cells (VPCs) during the early L3 stage, with later expression in the VPCs generally restricted to P6.p; lag-2 expression in the vulval cells is regulated by the LET-23/EGF receptor signaling pathway and the SUR-2 component of the Mediator transcription complex.
KOG Annotation  Proteins containing Ca2+-binding EGF-like domains
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 1125
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "Y73C8B.4" Links  Wormbase NCBI
WBRNAi00038575 Phenotypes Help with Phenotypes
Phenotype  Unclassified
WBRNAi00038575 Experiment Details Ace View
Laboratory  GS
RNAi Reagent & Type  probe_1:Y73C8B (Unknown_reagent_type)
Strain  N2
Remark  lag-2(RNAi-L1) animals display 2 AC (anchor cell) phenotype.
Reference  Karp X et al. (2004) Developmental Biology "Multiple roles for the E/Daughterless ortholog HLH-2 during C. elegans ...."
Delivery Method  Bacterial_feeding
Date  2004-7-02
Gene Plot of Y73C8B.4 Browse using GBrowse
Gene Graph