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RNAi Experiment: WBRNAi00059906 Ace View of WBRNAi00059906
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F47F6.1 (lin-42)
Description of "F47F6.1"  lin-42 encodes a PAS domain-containing protein orthologous to the insect and mammalian Period proteins that function in the timing of circadian rhythms; during postembryonic development, lin-42 activity is required for the switch from larval to adult fates that occurs in the hypodermal seam cells during the fourth and final molt; as a component of the heterochronic pathway, genetic analysis suggests that lin-42 likely acts early in the heterochronic pathway, either downstream of or in parallel to lin-46, which encodes a predicted scaffolding protein required for L3- and adult-specific cell fates; during larval development, lin-42 mRNA levels oscillate with peak levels apparent during larval intermolts and low levels seen during ecdysis and after the L4-to-adult molt; a rescuing LIN-42::GFP fusion protein is expressed in lateral hypodermal cells, the hypodermal syncytium, and head and tail hypodermal cells beginning during late embryogenesis and continuing through adulthood; within cells, LIN-42 is detected at generally higher levels in nuclei than in cytoplasm, although expression in the latter is enhanced during the larval molts.
Evidence for Inhibition 
Sliding Window Raw score: 768
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F47F6.1" Links  Wormbase NCBI
WBRNAi00059906 Phenotypes Help with Phenotypes
Phenotype  Unclassified lin-42(RNAi) substantially increased the survival rate of let-7(n2853ts) animals. It also partially restored alae formation in let-7(n2853ts) young adult animals.
WBRNAi00059906 Experiment Details Ace View
Laboratory  CT
RNAi Reagent & Type  probe_1:F47F6 (Unknown_reagent_type)
Strain  MT7626
Reference  Banerjee D et al. (2005) Dev Cell "Developmental Timing in C. elegans Is Regulated by kin-20 and tim-1, Homologs of ...."
Delivery Method  Bacterial_feeding
Date  2004-12-02
Gene Plot of F47F6.1 Browse using GBrowse
Gene Graph