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RNAi Experiment: WBRNAi00059910 Ace View of WBRNAi00059910
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F47F6.1 (lin-42)
Description of "F47F6.1"  lin-42 encodes a PAS domain-containing protein orthologous to the insect and mammalian Period proteins that function in the timing of circadian rhythms; during postembryonic development, lin-42 activity is required for the switch from larval to adult fates that occurs in the hypodermal seam cells during the fourth and final molt; as a component of the heterochronic pathway, genetic analysis suggests that lin-42 likely acts early in the heterochronic pathway, either downstream of or in parallel to lin-46, which encodes a predicted scaffolding protein required for L3- and adult-specific cell fates; during larval development, lin-42 mRNA levels oscillate with peak levels apparent during larval intermolts and low levels seen during ecdysis and after the L4-to-adult molt; a rescuing LIN-42::GFP fusion protein is expressed in lateral hypodermal cells, the hypodermal syncytium, and head and tail hypodermal cells beginning during late embryogenesis and continuing through adulthood; within cells, LIN-42 is detected at generally higher levels in nuclei than in cytoplasm, although expression in the latter is enhanced during the larval molts.
Evidence for Inhibition 
Sliding Window Raw score: 768
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F47F6.1" Links  Wormbase NCBI
WBRNAi00059910 Phenotypes Help with Phenotypes
Phenotype  Unclassified The precocious alae secretion phenotype that is observed in lin-41(ma104) lf mutants is modestly, but reproducibly, enhanced on lin-42(RNAi).
WBRNAi00059910 Experiment Details Ace View
Laboratory  CT
RNAi Reagent & Type  probe_1:F47F6 (Unknown_reagent_type)
Strain  CT8
Reference  Banerjee D et al. (2005) Dev Cell "Developmental Timing in C. elegans Is Regulated by kin-20 and tim-1, Homologs of ...."
Delivery Method  Bacterial_feeding
Date  2004-12-02
Gene Plot of F47F6.1 Browse using GBrowse
Gene Graph