RNAi Experiment: WBRNAi00059912 |
Ace View of WBRNAi00059912
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Genes Inhibited |
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Gene Inhibited |
F47F6.1 (lin-42) |
Description of "F47F6.1" |
lin-42 encodes a PAS domain-containing protein orthologous to the insect and mammalian Period proteins that function in the timing of circadian rhythms; during postembryonic development, lin-42 activity is required for the switch from larval to adult fates that occurs in the hypodermal seam cells during the fourth and final molt; as a component of the heterochronic pathway, genetic analysis suggests that lin-42 likely acts early in the heterochronic pathway, either downstream of or in parallel to lin-46, which encodes a predicted scaffolding protein required for L3- and adult-specific cell fates; during larval development, lin-42 mRNA levels oscillate with peak levels apparent during larval intermolts and low levels seen during ecdysis and after the L4-to-adult molt; a rescuing LIN-42::GFP fusion protein is expressed in lateral hypodermal cells, the hypodermal syncytium, and head and tail hypodermal cells beginning during late embryogenesis and continuing through adulthood; within cells, LIN-42 is detected at generally higher levels in nuclei than in cytoplasm, although expression in the latter is enhanced during the larval molts. |
Evidence for Inhibition |
Sliding Window |
Raw score: 768
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "F47F6.1" Links |
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WBRNAi00059912 Phenotypes |
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Phenotype |
Unclassified
hbl-1(mg285) lf animals on lin-42(RNAi) showed an enhancement in the formation of precocious alae
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WBRNAi00059912 Experiment Details |
Ace View |
Laboratory |
CT |
RNAi Reagent & Type |
probe_1:F47F6 (Unknown_reagent_type) |
Strain |
CT11 |
Reference |
Banerjee D et al. (2005) Dev Cell "Developmental Timing in C. elegans Is Regulated by kin-20 and tim-1, Homologs of ...." |
Delivery Method |
Bacterial_feeding |
Date |
2004-12-02 |
Gene Plot of F47F6.1 |
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