| RNAi Experiment: WBRNAi00059917 |
Ace View of WBRNAi00059917
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| Genes Inhibited |
 |
| Gene Inhibited |
Y65B4A.8 |
| Description of "Y65B4A.8" |
Associated GO Term : nucleotidyltransferase activity |
| KOG Annotation |
Predicted nucleotidyltransferase
Similar to bacterial dephospho-CoA kinase
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|
| Evidence for Inhibition |
| Sliding Window |
Raw score: 191
Relative score: 0.096 (Best raw score= for Gene )
Specificity index: 0.085 |
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| External "Y65B4A.8" Links |
  |
| Gene Inhibited |
ZK256.1 (pmr-1) |
| Description of "ZK256.1" |
The pmr-1 gene encodes a Golgi P-type ATPase Ca^2+/Mn^2+-pump; mutations in its human ortholog, ATP2C1, cause Hailey-Hailey disease (OMIM:169600). |
| KOG Annotation |
Ca2+ transporting ATPase
|
|
| Evidence for Inhibition |
| Sliding Window |
Raw score: 2741
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.887 |
| Wormbase (BLAST) |
RNAi primary |
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| External "ZK256.1" Links |
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| Gene Inhibited |
F57G9.6 |
| Evidence for Inhibition |
| Sliding Window |
Raw score: 59 |
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| External "F57G9.6" Links |
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| Gene Inhibited |
F12A10.6 |
| KOG Annotation |
Serine/threonine kinase (haspin family)
|
|
| Evidence for Inhibition |
| Sliding Window |
Raw score: 62
Relative score: 0.031 (Best raw score= for Gene )
Specificity index: 0.028 |
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| External "F12A10.6" Links |
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| WBRNAi00059917 Phenotypes |
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|
| Phenotype |
Stress Resistance
Upon growing on plates containing 20 mM EGTA, the survival rate of pmr-1 RNAi-treated worms decreased up to 23% compared to control gfp RNAi treated worms (N2, 4.4 +- 0.3 days; gfp RNAi, 4.3 +- 0.2 days; pmr-1 RNAi, 3.3 +- 0.3 days). The survival rate of pmr-1 RNAi worms decreased up to 32% when grown on plates with 20 mM MnCl2 (N2: 4.5 +- 0.3 days, gfp RNAi: 4.4 +- 0.5 days, pmr-1 RNAi: 3.0 +- 0.3 days). However, pmr-1 RNAi-treated worms showed dramatically increased paraquat resistance (survival rate increased up to 39%) compared to gfp RNAi treated animals.
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| WBRNAi00059917 Experiment Details |
Ace View |
| Laboratory |
KJ |
| RNAi Reagent & Type |
yk218a11 (cDNA_reagent) |
| Strain |
N2 |
| Reference |
Cho JH et al. (2005) FEBS Lett "Caenorhabditis elegans PMR1, a P-type calcium ATPase, is important for ...." |
| Delivery Method |
Injection |
| Date |
2004-12-09 |
| Gene Plot of ZK256.1 |
Browse using GBrowse
|
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| Gene Plot of Y65B4A.8 |
Browse using GBrowse
|
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| Gene Plot of F57G9.6 |
Browse using GBrowse
|
 |
| Gene Plot of F12A10.6 |
Browse using GBrowse
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 |
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