RNAi Experiment: WBRNAi00059917 |
Ace View of WBRNAi00059917
|
Genes Inhibited |
 |
Gene Inhibited |
Y65B4A.8 |
Description of "Y65B4A.8" |
Associated GO Term : nucleotidyltransferase activity |
KOG Annotation  |
Predicted nucleotidyltransferase Similar to bacterial dephospho-CoA kinase
|
 |
Evidence for Inhibition |
Sliding Window |
Raw score: 191
Relative score: 0.096 (Best raw score= for Gene )
Specificity index: 0.085 |
|
External "Y65B4A.8" Links |
 |
Gene Inhibited |
ZK256.1 (pmr-1) |
Description of "ZK256.1" |
The pmr-1 gene encodes a Golgi P-type ATPase Ca^2+/Mn^2+-pump; mutations in its human ortholog, ATP2C1, cause Hailey-Hailey disease (OMIM:169600). |
KOG Annotation  |
Ca2+ transporting ATPase
|
 |
Evidence for Inhibition |
Sliding Window |
Raw score: 2741
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.887 |
Wormbase (BLAST) |
RNAi primary |
|
External "ZK256.1" Links |
 |
Gene Inhibited |
F57G9.6 |
Evidence for Inhibition |
Sliding Window |
Raw score: 59 |
|
External "F57G9.6" Links |
 |
Gene Inhibited |
F12A10.6 |
KOG Annotation  |
Serine/threonine kinase (haspin family)
|
 |
Evidence for Inhibition |
Sliding Window |
Raw score: 62
Relative score: 0.031 (Best raw score= for Gene )
Specificity index: 0.028 |
|
External "F12A10.6" Links |
 |
WBRNAi00059917 Phenotypes |
|
 |
Phenotype |
Stress Resistance
Upon growing on plates containing 20 mM EGTA, the survival rate of pmr-1 RNAi-treated worms decreased up to 23% compared to control gfp RNAi treated worms (N2, 4.4 +- 0.3 days; gfp RNAi, 4.3 +- 0.2 days; pmr-1 RNAi, 3.3 +- 0.3 days). The survival rate of pmr-1 RNAi worms decreased up to 32% when grown on plates with 20 mM MnCl2 (N2: 4.5 +- 0.3 days, gfp RNAi: 4.4 +- 0.5 days, pmr-1 RNAi: 3.0 +- 0.3 days). However, pmr-1 RNAi-treated worms showed dramatically increased paraquat resistance (survival rate increased up to 39%) compared to gfp RNAi treated animals.
|
WBRNAi00059917 Experiment Details |
Ace View |
Laboratory |
KJ |
RNAi Reagent & Type |
yk218a11 (cDNA_reagent) |
Strain |
N2 |
Reference |
Cho JH et al. (2005) FEBS Lett "Caenorhabditis elegans PMR1, a P-type calcium ATPase, is important for ...." |
Delivery Method |
Injection |
Date |
2004-12-09 |
Gene Plot of ZK256.1 |
Browse using GBrowse
|
 |
Gene Plot of Y65B4A.8 |
Browse using GBrowse
|
 |
Gene Plot of F57G9.6 |
Browse using GBrowse
|
 |
Gene Plot of F12A10.6 |
Browse using GBrowse
|
 |