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RNAi Experiment: WBRNAi00059926 Ace View of WBRNAi00059926
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  B0464.7 (baf-1)
Description of "B0464.7"  baf-1 encodes a small, novel protein that is highly conserved amongst metazoa; BAF-1 binds double-stranded DNA nonspecifically in vitro and is essential for proper chromosome segregation, embryogenesis, and gonad development in vivo; biochemical and phenotypic analyses suggest that BAF-1 functions as an intramolecular bridge that mediates nuclear assembly and chromatin capture by the reforming nuclear envelope; by homology with mammalian BAF proteins, BAF-1 is also predicted to play a role in regulating gene expression and higher-order chromatin structure; during interphase, BAF-1 colocalizes with LMN-1/lamin to the nuclear envelope and nuclear interior; during mitosis, BAF-1 is present in a more punctate pattern, localizing near condensing chromatin and maintaining this localization through telophase; BAF-1 localization during nuclear assembly requires the activity of LMN-1/lamin, EMR-1/emerin, and LEM-2/MAN1.
KOG Annotation  DNA-bridging protein BAF
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 422
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "B0464.7" Links  Wormbase NCBI
WBRNAi00059926 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
WBRNAi00059926 Experiment Details Ace View
Laboratory  KM
RNAi Reagent & Type  yk333d11 (cDNA_reagent)
Reference  Zheng R et al. (2000) Proceedings of the National Academy of Sciences USA "Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, ...."
Delivery Method  Injection
Date  2000-8-01
Gene Plot of B0464.7 Browse using GBrowse
Gene Graph