RNAi Experiment: WBRNAi00059926 |
Ace View of WBRNAi00059926
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Genes Inhibited |
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Gene Inhibited |
B0464.7 (baf-1) |
Description of "B0464.7" |
baf-1 encodes a small, novel protein that is highly conserved amongst metazoa; BAF-1 binds double-stranded DNA nonspecifically in vitro and is essential for proper chromosome segregation, embryogenesis, and gonad development in vivo; biochemical and phenotypic analyses suggest that BAF-1 functions as an intramolecular bridge that mediates nuclear assembly and chromatin capture by the reforming nuclear envelope; by homology with mammalian BAF proteins, BAF-1 is also predicted to play a role in regulating gene expression and higher-order chromatin structure; during interphase, BAF-1 colocalizes with LMN-1/lamin to the nuclear envelope and nuclear interior; during mitosis, BAF-1 is present in a more punctate pattern, localizing near condensing chromatin and maintaining this localization through telophase; BAF-1 localization during nuclear assembly requires the activity of LMN-1/lamin, EMR-1/emerin, and LEM-2/MAN1. |
KOG Annotation  |
DNA-bridging protein BAF
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Evidence for Inhibition |
Sliding Window |
Raw score: 422
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "B0464.7" Links |
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WBRNAi00059926 Phenotypes |
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Embryonic |
Emb Penetrance None reported |
WBRNAi00059926 Experiment Details |
Ace View |
Laboratory |
KM |
RNAi Reagent & Type |
yk333d11 (cDNA_reagent) |
Reference |
Zheng R et al. (2000) Proceedings of the National Academy of Sciences USA "Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, ...." |
Delivery Method |
Injection |
Date |
2000-8-01 |
Gene Plot of B0464.7 |
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