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RNAi Experiment: WBRNAi00060227 Ace View of WBRNAi00060227
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F57F5.5 (pkc-1)
Description of "F57F5.5"  pkc-1 encodes a serine/threonine protein kinase that is orthologous to mammalian protein kinase C epsilon (PRKCE), a member of the nPKC subgroup of the protein kinase C superfamily; together with UNC-13, PKC-1 may act downstream of goa-1 to modulate phorbol ester-induced stimulation of acetylcholine release at NMJs; PKC-1 positively regulates locomotion, and affects thermotaxis and chemotaxis together with kin-11; PKC-1 is required for regulating several behaviors including sensation of volatile and soluble compounds, osmolarity, and temperature (thermosensation); PKC-1 is also required for phorbolester-induced stimulation of acetylcholine release at neuromuscular junctions; PKC-1 localizes to the processes and cell bodies of approximately 75 sensory neurons and interneurons, and pkc-1 mRNA is detectable at varying levels during larval and adult stages.
KOG Annotation  Serine/threonine protein kinase
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (V:12019015..12020178)
Transcript overlap: 703 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 600
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F57F5.5" Links  Wormbase NCBI
WBRNAi00060227 Phenotypes Help with Phenotypes
Phenotype  aldicarb_resistant Animals displayed resistance to paralysis on aldicarb in 4 out of 4 trials.
WBRNAi00060227 Experiment Details Ace View
Laboratory  KP
RNAi Reagent & Type  sjj_F57F5.5 (PCR_reagent)
Reference  Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...."
Delivery Method  Bacterial_feeding
Date  2005-5-09
Gene Plot of F57F5.5 Browse using GBrowse
Gene Graph