| RNAi Experiment: WBRNAi00060407 |
Ace View of WBRNAi00060407
|
| Genes Inhibited |
 |
| Gene Inhibited |
C43E11.6 (nab-1) |
| Description of "C43E11.6" |
nab-1 encodes a PDZ and SAM domain-containing protein that is the sole C. elegans ortholog of the mammalian Neurabin/Spinophilin proteins; by homology, NAB-1 is predicted to interact with F-actin, ZYG-8/Doublecortin and the SAD-1 serine/threonine kinase to regulate interactions between the actin and microtubule networks during cell migration, growth cone guidance, and cell division; loss of nab-1 activity via RNAi has been reported to result in early embryonic lethality, dumpy and left-handed roller animals, as well as abnormalities in germ-line development and vulval morphogenesis; in large-scale screens, nab-1 RNAi did not result in any obvious abnormalities; NAB-1 translational reporter fusions show expression in hypodermal cells, neurons, and muscle. |
| Evidence for Inhibition |
| ePCR |
Status: Unique_ePCR (I:4234010..4235165)
Transcript overlap: 863 nt |
|
| Sliding Window |
Raw score: 822
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
| Wormbase (BLAST) |
RNAi primary |
|
| External "C43E11.6" Links |
  |
| WBRNAi00060407 Phenotypes |
|
|
| Phenotype |
WT
|
| WBRNAi00060407 Experiment Details |
Ace View |
| Laboratory |
KP |
| RNAi Reagent & Type |
sjj_C43E11.6 (PCR_reagent) |
| Reference |
Sieburth D et al. (2005) Nature "Systematic analysis of genes required for synapse structure and ...." |
| Delivery Method |
Bacterial_feeding |
| Date |
2005-5-09 |
| Gene Plot of C43E11.6 |
Browse using GBrowse
|
 |
![Adult](JavaScript:void
window.open("/cgi-bin/rnaidb/popUpImage.cgi?imgName=N2wormfinal.png",
"RNAiDB Help","toolbar=no, location=no, directories=no,
status=no, menubar=no, scrollbars=yes, resizable=no,
copyhistory=no, width=1000, height=550"))
