RNAi Experiment: [cgc4544]:air-2 |
Ace View of [cgc4544]:air-2
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Genes Inhibited |
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Gene Inhibited |
B0207.4 (air-2) |
Description of "B0207.4" |
air-2 encodes an aurora/Ip11-related serine/threonine protein kinase that affects embryonic viability and chromosome segregation during meiosis and mitosis and is required for cytokinesis; AIR-2 has two functions during mitosis, one in chromosome segregation, and a second, independent function in cytokinesis through ZEN-4; AIR-2 and ZEN-4 may act in parallel to a second pathway that includes CYK-1; AIR-2 phosphorylates two adjacent, evolutionarily conserved C-terminal serines of the inner centromere protein ICP-1; AIR-2 forms a robust complex with CSC-1, BIR-1, and ICP-1; air-2 is expressed highly in embryos, in the mature oocytes, spermatocytes, and extruded polar bodies. |
KOG Annotation  |
Serine/threonine protein kinase
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Evidence for Inhibition |
Sliding Window |
Raw score: 912
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "B0207.4" Links |
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[cgc4544]:air-2 Phenotypes |
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Embryonic |
Emb Penetrance None reported |
[cgc4544]:air-2 Experiment Details |
Ace View |
Laboratory |
EU |
RNAi Reagent & Type |
yk483g8 (cDNA_reagent) |
Remark |
DIC phenotype -- Reduced cleavage furrow ingression in second embryonic division; a phenotype not observed in either single (or36 mutation or air-2 RNAi) treatments, cf RNAi [cgc4544]:zen-4 |
Reference |
Severson AF et al. (2000) Current Biology "The Aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle ...." |
Delivery Method |
Injection |
Date |
2000-9-11 |
Gene Plot of B0207.4 |
Browse using GBrowse
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