| Ace View of [cgc4761]:A2 | ||||||
| Gene Inhibited | W10G6.3 (mua-6) | |||||
| Description of "W10G6.3" | mua-6 encodes an essential intermediate filament protein (MUA-6/IFA-2) that is coexpressed with the essential IF protein IFB-1; MUA-6 is required for hypodermal integrity and for lasting attachment of muscles to the body wall; MUA-6 is also required for normal positioning of excretory canals and muscles; MUA-6 forms heteropolymeric intermediate filaments in vitro with an equimolar mixture of IFB-1; mua-6 is transcribed from L1 larval to adult stages; MUA-6 resides in main body hypodermal desmosomes, but not in seam cells. | |||||
| KOG Annotation | Nuclear envelope protein lamin, intermediate filament superfamily |
|||||
| Evidence for Inhibition |
|
|||||
| External "W10G6.3" Links |   |
|||||
| Gene Inhibited | F52E10.5 (ifa-3) | |||||
| Description of "F52E10.5" | ifa-3 encodes an essential intermediate filament protein that is coexpressed with the essential IF protein IFB-1; IFA-3 is required for survival past early larval stages, correct positioning of excretory canals and body muscles, attachment of cuticle to hypodermis, and locomotion; IFA-3 forms heteropolymeric intermediate filaments in vitro with an equimolar mixture of IFB-1; IFA-3 is expressed in embryonic and larval, but not adult, hypodermis. | |||||
| KOG Annotation | Nuclear envelope protein lamin, intermediate filament superfamily |
|||||
| Evidence for Inhibition |
|
|||||
| External "F52E10.5" Links | |
|||||
| Gene Inhibited | T06E6.12 (srh-263) | |||||
| Evidence for Inhibition |
|
|||||
| External "T06E6.12" Links | |
|||||
| Gene Inhibited | C38D9.10 (srg-43) | |||||
| Evidence for Inhibition |
|
|||||
| External "C38D9.10" Links | |
|||||
| Gene Inhibited | ZK1240.5 | |||||
| Description of "ZK1240.5" | Associated GO Term : zinc ion binding | |||||
| KOG Annotation | Predicted E3 ubiquitin ligase |
|||||
| Evidence for Inhibition |
|
|||||
| External "ZK1240.5" Links | |
|||||
| Larval | Lvl
Early larval lethality (85%), late larval arrest (15%) |
|||||
| Adult | Unc
paralysis |
|||||
| Phenotype | Unclassified
excretory canals uneven |
|||||
| RNAi Reagent & Type | [cgc4761]:A2 (PCR_reagent) | |||||
| Reference | Karabinos A et al. (2001) Proceedings of the National Academy of Sciences USA "Essential roles for four cytoplasmic intermediate filament proteins in ...." | |||||
| Delivery Method | Injection | |||||
| Date | 2001-7-03 | |||||
| Gene Plot of T06E6.12 | ||||||
 |
||||||
| Gene Plot of F52E10.5 | ||||||
 |
||||||
| Gene Plot of W10G6.3 | ||||||
 |
||||||
| Gene Plot of C38D9.10 | ||||||
 |
||||||
| Gene Plot of ZK1240.5 | ||||||
 |
||||||
![Adult](JavaScript:void
window.open("/cgi-bin/rnaidb/popUpImage.cgi?imgName=N2wormfinal.png",
"RNAiDB Help","toolbar=no, location=no, directories=no,
status=no, menubar=no, scrollbars=yes, resizable=no,
copyhistory=no, width=1000, height=550"))
 |
Please provide feedback if you are experiencing any difficulties with this website. |