Ace View of [cgc4997]:sep-1:2 | ||||||
Gene Inhibited | Y47G6A.12 (sep-1) | |||||
Description of "Y47G6A.12" | The sep-1 gene encodes a homolog of separase, a protease that splits segregating chromosomes at their centromeres during anaphase by proteolyzing the Scc1 subunit of cohesin. | |||||
KOG Annotation  | Regulator of spindle pole body duplication |
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Evidence for Inhibition |
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External "Y47G6A.12" Links | ||||||
Embryonic | Emb Penetrance None reported | |||||
Phenotype | Mei
alignment of bivalents on the first meiotic spindle occurred normally in sep-1(RNAi)embryos, but the chromosome segregation was delayed or never occured. |
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RNAi Reagent & Type | yk429h5 (cDNA_reagent) | |||||
Strain | N2 | |||||
Remark | RNAi was performed in H2B::GFP background | |||||
Reference | Siomos MF et al. (2001) Current Biology "Separase is required for chromosome segregation during meiosis I in ...." | |||||
Delivery Method | Soaking | |||||
Date | 2001-10-09 | |||||
Gene Plot of Y47G6A.12 | ||||||