RNAi Experiment: [cgc5261]:pat-4 |
Ace View of [cgc5261]:pat-4
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Genes Inhibited |
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Gene Inhibited |
C29F9.7 (pat-4) |
Description of "C29F9.7" |
The pat-4 gene encodes a serine/threonine kinase orthologous to human integrin-linked kinase (ILK, OMIM:602366) and is required for formation of integrin-mediated muscle cell attachments during embryogenesis; PAT-4 probably functions as an adaptor molecule and localizes to dense bodies and M lines; PAT-4 forms a ternary complex with PAT-6/actopaxin and UNC-112, and requires UNC-112, UNC-52/perlecan, PAT-2/alpha integrin, and PAT-3/beta integrin for proper localization to newly forming integrin adhesion complexes. |
KOG Annotation  |
Integrin-linked kinase
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Evidence for Inhibition |
Sliding Window |
Raw score: 1347
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "C29F9.7" Links |
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[cgc5261]:pat-4 Phenotypes |
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Embryonic |
Pat |
[cgc5261]:pat-4 Experiment Details |
Ace View |
Laboratory |
WB |
RNAi Reagent & Type |
yk199a2 (cDNA_reagent) |
Strain |
N2 |
Reference |
Mackinnon AC et al. (2002) Current Biology "C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion ...." |
Delivery Method |
Injection |
Date |
2002-3-07 |
Gene Plot of C29F9.7 |
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