RNAi Experiment: [cgc5277]:apr-1:1 |
Ace View of [cgc5277]:apr-1:1
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Genes Inhibited |
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Gene Inhibited |
K04G2.8 (apr-1) |
Description of "K04G2.8" |
The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39. |
KOG Annotation  |
Beta-catenin-binding protein APC, contains ARM repeats
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Evidence for Inhibition |
Sliding Window |
Raw score: 3741
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "K04G2.8" Links |
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[cgc5277]:apr-1:1 Phenotypes |
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Phenotype |
WT
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[cgc5277]:apr-1:1 Experiment Details |
Ace View |
Laboratory |
EW |
RNAi Reagent & Type |
[cgc5277]:apr-1 (cDNA_reagent) |
Strain |
N2 |
Remark |
To avoid embryonic lethality, animals were fed dsRNA-expressing bacteria starting at the L1 stage and the vulval phenotype of these same animals was examined later in the L4 stage. |
Reference |
Gleason JE et al. (2002) Genes & Development "Activatin of Wnt signaling bypasses the requirement for RTK/Ras signaling ...." |
Delivery Method |
Bacterial_feeding |
Date |
2002-3-29 |
Gene Plot of K04G2.8 |
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