RNAi Experiment: [cgc5370]:pmk-1 |
Ace View of [cgc5370]:pmk-1
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Genes Inhibited |
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Gene Inhibited |
B0218.3 (pmk-1) |
Description of "B0218.3" |
pmk-1 encodes a mitogen-activated protein kinase (MAPK), orthologous to human p38 MAPK (OMIM:600289), that is required for eliciting gonadal programmed cell death in response to Salmonella enterica infection; PMK-1 lies upstream of CED-9, a negative regulator of apoptosis, in the programmed cell death pathway. |
KOG Annotation  |
Mitogen-activated protein kinase
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Evidence for Inhibition |
Sliding Window |
Raw score: 1050
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "B0218.3" Links |
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[cgc5370]:pmk-1 Phenotypes |
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Phenotype |
Esp
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[cgc5370]:pmk-1 Experiment Details |
Ace View |
Laboratory |
AU |
RNAi Reagent & Type |
[cgc5370]:B0218 (cDNA_reagent) |
Strain |
WT |
Remark |
L4 worms prefed on HT115 bacteria carrying pmk-1 RNAi vector exhibit a strong enhancement of susceptibility to pathogens as judged by the slow killing assay using P. aeruginosa PA14 strain |
Reference |
Kim DH et al. (2002) Science "A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate ...." |
Delivery Method |
Bacterial_feeding |
Date |
2002-6-13 |
Gene Plot of B0218.3 |
Browse using GBrowse
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