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RNAi Experiment: [cgc5370]:pmk-1 Ace View of [cgc5370]:pmk-1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  B0218.3 (pmk-1)
Description of "B0218.3"  pmk-1 encodes a mitogen-activated protein kinase (MAPK), orthologous to human p38 MAPK (OMIM:600289), that is required for eliciting gonadal programmed cell death in response to Salmonella enterica infection; PMK-1 lies upstream of CED-9, a negative regulator of apoptosis, in the programmed cell death pathway.
KOG Annotation  Mitogen-activated protein kinase
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 1050
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "B0218.3" Links  Wormbase NCBI
[cgc5370]:pmk-1 Phenotypes Help with Phenotypes
Phenotype  Esp
[cgc5370]:pmk-1 Experiment Details Ace View
Laboratory  AU
RNAi Reagent & Type  [cgc5370]:B0218 (cDNA_reagent)
Strain  WT
Remark  L4 worms prefed on HT115 bacteria carrying pmk-1 RNAi vector exhibit a strong enhancement of susceptibility to pathogens as judged by the slow killing assay using P. aeruginosa PA14 strain
Reference  Kim DH et al. (2002) Science "A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate ...."
Delivery Method  Bacterial_feeding
Date  2002-6-13
Gene Plot of B0218.3 Browse using GBrowse
Gene Graph