Link to C06G4.2a.1Link to C06G4.2b.3Link to C06G4.2b.1Link to C06G4.2a.2Link to C06G4.2b.2Link to C06G4.2dLink to C06G4.2cRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 
RNAi Experiment: [cgc5513]:clp-1:3 Ace View of [cgc5513]:clp-1:3
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C06G4.2 (clp-1)
Description of "C06G4.2"  clp-1 encodes a calpain homolog that has significant identity to mammalian calpains over its whole length and that contains motifs typical of calpains, including a thiol (cysteine) protease active site and a Ca[2+]-binding domain; CLP-1 is required, in parallel with TRA-3 but in series with ASP-3 and ASP-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf).
Evidence for Inhibition 
Sliding Window Raw score: 1805
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C06G4.2" Links  Wormbase NCBI
[cgc5513]:clp-1:3 Phenotypes Help with Phenotypes
Phenotype  Ced Suppresses neurodegeneration caused by nuIs5[pglr-1::Galphas(Q227L) pglr-1::GFP]
[cgc5513]:clp-1:3 Experiment Details Ace View
Laboratory  IR
RNAi Reagent & Type  [cgc5513]:C06G4 (cDNA_reagent)
Remark  RNAi was performed in nuIs5[pglr-1::Galphas(Q227L) pglr-1::GFP] background.
Reference  Syntichaki P et al. (2002) Nature "Specific aspartyl and calpain proteases are required for neurodegeneration in ...."
Delivery Method  Injection
Date  2002-8-21
Gene Plot of C06G4.2 Browse using GBrowse
Gene Graph