RNAi Experiment: [cgc5513]:clp-1:3 |
Ace View of [cgc5513]:clp-1:3
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Genes Inhibited |
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Gene Inhibited |
C06G4.2 (clp-1) |
Description of "C06G4.2" |
clp-1 encodes a calpain homolog that has significant identity to mammalian calpains over its whole length and that contains motifs typical of calpains, including a thiol (cysteine) protease active site and a Ca[2+]-binding domain; CLP-1 is required, in parallel with TRA-3 but in series with ASP-3 and ASP-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf). |
Evidence for Inhibition |
Sliding Window |
Raw score: 1805
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "C06G4.2" Links |
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[cgc5513]:clp-1:3 Phenotypes |
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Phenotype |
Ced
Suppresses neurodegeneration caused by nuIs5[pglr-1::Galphas(Q227L) pglr-1::GFP]
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[cgc5513]:clp-1:3 Experiment Details |
Ace View |
Laboratory |
IR |
RNAi Reagent & Type |
[cgc5513]:C06G4 (cDNA_reagent) |
Remark |
RNAi was performed in nuIs5[pglr-1::Galphas(Q227L) pglr-1::GFP] background. |
Reference |
Syntichaki P et al. (2002) Nature "Specific aspartyl and calpain proteases are required for neurodegeneration in ...." |
Delivery Method |
Injection |
Date |
2002-8-21 |
Gene Plot of C06G4.2 |
Browse using GBrowse
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