Link to Y17G7B.15bLink to Y17G7B.15aRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 
RNAi Experiment: [cgc5655]:Y17G7B.15 Ace View of [cgc5655]:Y17G7B.15
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  Y17G7B.15 (cnt-1)
Description of "Y17G7B.15"  cnt-1 encodes a homolog of centaurin beta, an Arf GTPase activating protein (Arf GAP) that also contains a pleckstrin homology domain and C-terminal ankyrin repeats; by homology, CNT-1 is predicted to function as an Arf GAP that stimulates Arf GTPase activity and links cell signaling with cytoskeletal rearrangements and membrane trafficking; however, as loss of cnt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cnt-1 in C. elegans development and/or behavior is not yet known; cnt-1 is broadly expressed, being detected in the pharynx, excretory cell, spermatheca, distal tip cells of the gonad, neurons of the head and nerve ring, and anal epithelial cells; CNT-1 is able to bind the phosphoinositides PIP2 and PIP3 and upon production of PIP3, can translocate from the cytoplasm to the membrane.
KOG Annotation  Putative GTPase activating proteins (GAPs)
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (II:12073593..12075628)
Transcript overlap: 873 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 831
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "Y17G7B.15" Links  Wormbase NCBI
[cgc5655]:Y17G7B.15 Phenotypes Help with Phenotypes
Phenotype  Unclassified lipid metabolism abnormal
[cgc5655]:Y17G7B.15 Experiment Details Ace View
Laboratory  GR
RNAi Reagent & Type  sjj_Y17G7B.15 (PCR_reagent)
Reference  Ashrafi K et al. (2003) Nature "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory ...."
Delivery Method  Bacterial_feeding
Date  2003-1-10
Gene Plot of Y17G7B.15 Browse using GBrowse
Gene Graph