Ace View of [pmid12709403]:coq-5 | ||||||
Gene Inhibited | ZK652.10 (tag-307) | |||||
KOG Annotation  | Putative Mg2+ and Co2+ transporter CorD |
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Evidence for Inhibition |
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External "ZK652.10" Links | ||||||
Gene Inhibited | ZK652.9 (coq-5) | |||||
Description of "ZK652.9" | coq-5 encodes a putative ubiquinone biosynthesis methyltransferase, homologous to COQ5 in S. cerevisiae and a family of methyltransferases involved in ubiquinone, menaquinone, biotin and sterol biosynthesis and in phosphatidylethanolamine methylation; COQ-5 is required for ubiquinone biosynthesis and for normally short lifespan; coq-5(RNAi) animals have reduced levels of coenzyme Q8, coenzyme Q9, and superoxide, and have abnormally long lifespans. | |||||
KOG Annotation  | Ubiquinone biosynthesis methyltransferase COQ5 |
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Evidence for Inhibition |
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External "ZK652.9" Links | ||||||
Phenotype | Age Unclassified decrease in superoxide production |
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RNAi Reagent & Type | [pmid12709403]:coq-5 (PCR_reagent) | |||||
Reference | Asencio C et al. (2003) FASEB J "Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis ...." | |||||
Delivery Method | Bacterial_feeding | |||||
Date | 2003-4-22 | |||||
Gene Plot of ZK652.10 | ||||||
Gene Plot of ZK652.9 | ||||||