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Gene: B0379.3   

B0379.3EvidencePerson_evidenceWBPerson490
SMapS_parentSequenceB0379
ChromosomeI
Identity (5)
Gene_info Gene_classmut
GO_term (5)
Structured_description Provisional_description mut-16 encodes a glutamine/asparagine (Q/N)-rich domain-containing protein that lacks obvious homologs outside of other nematode species; MUT-16 activity is required for RNA-mediated interference (RNAi), transgene silencing in germ-line and somatic tissues, and for maintaining low levels of transposon mobilization; MUT-16 is thus predicted to play a role in chromatin organizataion and/or regulation of gene expression. Paper_evidence (7)
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
Proteins bearing such domains can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain.
Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.
Therefore, it is possible that this gene's protein product undergoes epigenetic control of protein activity, through heritable epigenetic modulation of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells.
It is important to note that this is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis.
Concise_descriptionmut-16 encodes a glutamine/asparagine (Q/N)-rich domain-containing protein that lacks obvious homologs outside of other nematode species; MUT-16 activity is required for RNA-mediated interference (RNAi), transgene silencing in germ-line and somatic tissues, and for maintaining low levels of transposon mobilization; MUT-16 is thus predicted to play a role in chromatin organizataion and/or regulation of gene expression.
Molecular_info (5)
Experimental_info RNAi_result Cenix:145-f8
Cenix:18-e1
JA:B0379.3
WB_RNAi_result JA:B0379.3
Cenix:145-f8
Cenix:18-e1
InteractionWBInteraction0002320
Reference (10)
MethodGene