Gene: C09D8.1
C09D8.1 | SMap | S_parent | Sequence | SUPERLINK_CB_II | |||||
---|---|---|---|---|---|---|---|---|---|
Chromosome | II | ||||||||
Identity | Version | 1 | |||||||
Name | CGC_name | ptp-3 | Person_evidence | WBPerson250 | |||||
Sequence_name | C09D8.1 | ||||||||
Molecular_name (9) | |||||||||
Other_name (5) | |||||||||
Public_name | ptp-3 | ||||||||
Synonym (16) | |||||||||
WBGeneID | WBGene00004215 | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Gene_class | ptp | |||||||
Allele | ok244 | Inferred_automatically | From strain object: RB633 | ||||||
op147 | Paper_evidence | WBPaper00005259 | |||||||
Inferred_automatically | From strain object: CZ540 | ||||||||
mu256 | Paper_evidence | WBPaper00026711 | |||||||
tm352 | |||||||||
snp_C09D8[1] | |||||||||
snp_C09D8[2] | |||||||||
uCE2-1949 | |||||||||
uCE2-1950 | |||||||||
uCE2-1951 | |||||||||
uCE2-1952 | |||||||||
Phenotype | [Chisholm AD] op147 mutation is a Tc1 insertion in the first phosphatase domain of PTP-1. op147 mutants display variable low penetrance defects in epidermal morphogenesis; about 5% embryonic lethals at 20. op147 is slightly ts. | ||||||||
[C.elegansII] NMK. Encodes predicted tyrosine phosphatase. [CR] | |||||||||
Strain | CZ540 | ||||||||
RB633 | |||||||||
GO_term (8) | |||||||||
Structured_description | Provisional_description | ptp-3 encodes a receptor-like tyrosine phosphatase orthologous to the LAR (Leukocyte Common Antigen Related, OMIM:179590) subfamily of receptor-like tyrosine phosphatases that contain extracellular immunoglobulin-like and fibronectin type III domains and have been implicated in linking cell adhesion to intracellular phosphotyrosine levels; PTP-3 plays a role in gastrulation and epidermal development and functions partly redundantly with the VAB-1 Eph receptor and ephrins VAB-2 and EFN-4 to regulate embryonic morphogenesis; PTP-3 is expressed in many tissues during early embryogenesis, but expression later becomes localized to neuronal processes and epithelial adherens junctions. | Paper_evidence (2) | ||||||
Person_evidence | WBPerson1843 | ||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Concise_description | ptp-3 encodes a receptor-like tyrosine phosphatase orthologous to the LAR (Leukocyte Common Antigen Related, OMIM:179590) subfamily of receptor-like tyrosine phosphatases that contain extracellular immunoglobulin-like and fibronectin type III domains and have been implicated in linking cell adhesion to intracellular phosphotyrosine levels; PTP-3 plays a role in gastrulation and epidermal development and functions partly redundantly with the VAB-1 Eph receptor and ephrins VAB-2 and EFN-4 to regulate embryonic morphogenesis; PTP-3 is expressed in many tissues during early embryogenesis, but expression later becomes localized to neuronal processes and epithelial adherens junctions. | ||||||||
Molecular_info | Corresponding_CDS | C09D8.1a | |||||||
C09D8.1b | |||||||||
C09D8.1c | |||||||||
Corresponding_CDS_history | C09D8.1:wp72 | ||||||||
Corresponding_protein | WP:CE30244 | ||||||||
WP:CE30245 | |||||||||
WP:CE32793 | |||||||||
Corresponding_PCR_product | smd_C09D8.1 | ||||||||
smd_C09D8.2 | |||||||||
sjj_C09D8.2 | |||||||||
sjj_C09D8.1 | |||||||||
Corresponding_RNAi_reagent (5) | |||||||||
Other_sequence | AF316539 | ||||||||
AF316540 | |||||||||
Experimental_info (5) | |||||||||
Reference (14) | |||||||||
Remark | Worm ortholog of LAR-family receptor tyrosine phosphatases Worm ortholog of LAR-family receptor tyrosine phosphatase. Chisholm AD | ||||||||
This gene was originally called ptp-1 (and ypp-1 before that), but ptp-1 is now a separate and different gene [020809 krb] | |||||||||
Method | Gene |