C09D8.1 | SMap | S_parent | Sequence | SUPERLINK_CB_II
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| Chromosome | II |
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Identity (5)
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Gene_info
| Gene_class | ptp
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Allele (10)
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Phenotype
| [Chisholm AD] op147 mutation is a Tc1 insertion in the first phosphatase domain of PTP-1. op147 mutants display variable low penetrance defects in epidermal morphogenesis; about 5% embryonic lethals at 20. op147 is slightly ts. |
| | | [C.elegansII] NMK. Encodes predicted tyrosine phosphatase. [CR] |
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Strain (2)
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GO_term (8)
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Structured_description
| Provisional_description | ptp-3 encodes a receptor-like tyrosine phosphatase orthologous to the LAR (Leukocyte Common Antigen Related, OMIM:179590) subfamily of receptor-like tyrosine phosphatases that contain extracellular immunoglobulin-like and fibronectin type III domains and have been implicated in linking cell adhesion to intracellular phosphotyrosine levels; PTP-3 plays a role in gastrulation and epidermal development and functions partly redundantly with the VAB-1 Eph receptor and ephrins VAB-2 and EFN-4 to regulate embryonic morphogenesis; PTP-3 is expressed in many tissues during early embryogenesis, but expression later becomes localized to neuronal processes and epithelial adherens junctions. |
Paper_evidence (2)
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| | | | | Person_evidence | WBPerson1843
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| | | | | Curator_confirmed | WBPerson1843
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Concise_description | ptp-3 encodes a receptor-like tyrosine phosphatase orthologous to the LAR (Leukocyte Common Antigen Related, OMIM:179590) subfamily of receptor-like tyrosine phosphatases that contain extracellular immunoglobulin-like and fibronectin type III domains and have been implicated in linking cell adhesion to intracellular phosphotyrosine levels; PTP-3 plays a role in gastrulation and epidermal development and functions partly redundantly with the VAB-1 Eph receptor and ephrins VAB-2 and EFN-4 to regulate embryonic morphogenesis; PTP-3 is expressed in many tissues during early embryogenesis, but expression later becomes localized to neuronal processes and epithelial adherens junctions. |
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Molecular_info
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Corresponding_CDS
| C09D8.1a
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| | | C09D8.1b
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| | | C09D8.1c
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| | Corresponding_CDS_history | C09D8.1:wp72
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Corresponding_protein
| WP:CE30244
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| | | WP:CE30245
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| | | WP:CE32793
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Corresponding_PCR_product
| smd_C09D8.1
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| | | smd_C09D8.2
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| | | sjj_C09D8.2
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| | | sjj_C09D8.1
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Corresponding_RNAi_reagent (5)
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Other_sequence
| AF316539
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| | | AF316540
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Experimental_info (5)
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Reference (14)
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Remark
| Worm ortholog of LAR-family receptor tyrosine phosphatases Worm ortholog of LAR-family receptor tyrosine phosphatase. Chisholm AD |
| | This gene was originally called ptp-1 (and ypp-1 before that), but ptp-1 is now a separate and different gene [020809 krb] |
| Method | Gene
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