C09D8.1 | SMap | S_parent | Sequence | SUPERLINK_CB_II
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| Chromosome | II |
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Identity
| Version | 1 |
| |
Name (7)
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| | Species | Caenorhabditis elegans
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| | History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971
| Event | Imported | Initial conversion from geneace |
| | Status | Live |
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Gene_info
| Gene_class | ptp
|
| |
Allele
| ok244
| Inferred_automatically | From strain object: RB633 |
| | |
op147 (2)
|
| | | mu256
| Paper_evidence | WBPaper00026711
|
| | | tm352
|
| | | snp_C09D8[1]
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| | | snp_C09D8[2]
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| | | uCE2-1949
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| | | uCE2-1950
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| | | uCE2-1951
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| | | uCE2-1952
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| |
Phenotype
| [Chisholm AD] op147 mutation is a Tc1 insertion in the first phosphatase domain of PTP-1. op147 mutants display variable low penetrance defects in epidermal morphogenesis; about 5% embryonic lethals at 20. op147 is slightly ts. |
| | | [C.elegansII] NMK. Encodes predicted tyrosine phosphatase. [CR] |
| |
Strain
| CZ540
|
| | | RB633
|
| |
GO_term (8)
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Structured_description
| Provisional_description | ptp-3 encodes a receptor-like tyrosine phosphatase orthologous to the LAR (Leukocyte Common Antigen Related, OMIM:179590) subfamily of receptor-like tyrosine phosphatases that contain extracellular immunoglobulin-like and fibronectin type III domains and have been implicated in linking cell adhesion to intracellular phosphotyrosine levels; PTP-3 plays a role in gastrulation and epidermal development and functions partly redundantly with the VAB-1 Eph receptor and ephrins VAB-2 and EFN-4 to regulate embryonic morphogenesis; PTP-3 is expressed in many tissues during early embryogenesis, but expression later becomes localized to neuronal processes and epithelial adherens junctions. |
Paper_evidence
| WBPaper00005259
|
| | | | | | WBPaper00005631
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| | | | | Person_evidence | WBPerson1843
|
| | | | | Curator_confirmed | WBPerson1843
|
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Concise_description | ptp-3 encodes a receptor-like tyrosine phosphatase orthologous to the LAR (Leukocyte Common Antigen Related, OMIM:179590) subfamily of receptor-like tyrosine phosphatases that contain extracellular immunoglobulin-like and fibronectin type III domains and have been implicated in linking cell adhesion to intracellular phosphotyrosine levels; PTP-3 plays a role in gastrulation and epidermal development and functions partly redundantly with the VAB-1 Eph receptor and ephrins VAB-2 and EFN-4 to regulate embryonic morphogenesis; PTP-3 is expressed in many tissues during early embryogenesis, but expression later becomes localized to neuronal processes and epithelial adherens junctions. |
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Molecular_info (6)
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Experimental_info (5)
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Reference (14)
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Remark
| Worm ortholog of LAR-family receptor tyrosine phosphatases Worm ortholog of LAR-family receptor tyrosine phosphatase. Chisholm AD |
| | This gene was originally called ptp-1 (and ypp-1 before that), but ptp-1 is now a separate and different gene [020809 krb] |
| Method | Gene
|