Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 

Gene: C25D7.3   

C25D7.3SMapS_parentSequenceC25D7
ChromosomeV
Identity (5)
Gene_info Gene_classsdc
Reference_alleley132
Allele (10)
Phenotype[C.elegansII] y126mat : deletion null, XX animals inviable if mother homozygous; rare escapers dumpy hermaphrodite; cryptic masculinization; XO phenotype WT.OA>10: y122, y127, y143 (similar); also sdc-3 (Tra)alleles: y52 (XX viable, masculinized), y137 (weaker); also sdc-3(Dpy) alleles: y100 (XX inviable or dumpy,no masculinization), y128 etc. Cloned: 7kb transcript present in embryo, L1, L2; encodes 2150 aa protein, possible ATP-binding site (affected in Tra mutations), 2 C-term zinc fingers (affected in Dpy mutations). [DeLong et al. 1993; Klein and Meyer 1993; TY]
Strain BS518
TY956
TY1077
TY1388
GO_term (7)
Structured_description Provisional_description sdc-3 encodes a protein that contains two mutationally separable domains: a zinc finger motif required for dosage compensation and a myosin- like putative ATP- binding region required for her-1 regulation of sex determination; SDC-3 activates dosage compensation by directing the dosage compensation protein complex to the hermaphrodite X chromosomes, and is functionally redundant with SDC-2 with respect to dosage compensation; SDC-1, SDC-2, and SDC-3 proteins form a complex. Paper_evidence (5)
Person_evidenceWBPerson48
Curator_confirmedWBPerson48
Date_last_updated17 Jun 2004 00:00:00
A complex of SDC-1, SDC-2, and SDC-3 proteins is detectable by coimmunoprecipitation; furthermore, SDC-1, SDC-2, and SDC-3 colocalize with DPY-26, DPY-27, and MIX-1 proteins both on a transgenic her-1(+) array and on the X chromosome.
Concise_descriptionsdc-3 encodes a protein that contains two mutationally separable domains: a zinc finger motif required for dosage compensation and a myosin- like putative ATP- binding region required for her-1 regulation of sex determination; SDC-3 activates dosage compensation by directing the dosage compensation protein complex to the hermaphrodite X chromosomes, and is functionally redundant with SDC-2 with respect to dosage compensation; SDC-1, SDC-2, and SDC-3 proteins form a complex.
Molecular_info (5)
Experimental_info (5)
Reference (83)
MethodGene