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Gene: C43E11.7   

C43E11.7SMapS_parentSequenceC43E11
ChromosomeI
Identity (5)
Gene_info Gene_classndx
Allele uCE1-820
uCE1-821
Contained_in_operonCEOP1160
Structured_description Provisional_description ndx-7 encodes a NUDIX hydrolase; by sequence comparison, NDX-7 is predicted to function as a pyrophosphatase, and is most closely related to the mouse RP2 protein that has unknown substrate specificity but is regulated transcriptionally by the presence of androgens; in C. elegans, loss of ndx-7 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, consistent with the proposed nonessential roles for Nudix proteins in eliminating potentially toxic nucleotide metabolites from cells and modulating levels of metabolic intermediates by shuttling them into alternative biochemical pathways. Paper_evidence WBPaper00004210
WBPaper00005401
WBPaper00005654
WBPaper00013536
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
NUDIX hydrolases are defined by the following array of amino acids: G[X.5]E[X.7]REU[X]EE[X]GU, called the NUDIX box, where U is hydrophobic, usually Ile, Leu or Val.
The acronym 'NUDIX' comes from the class of substrates hydrolysed by these enzymes.
The substrates are predominantly nucleoside diphosphates linked to some other moiety 'X'.
ndx-7 encodes one of 11 C. elegans Nudix (nucleoside diphosphate linked to another moiety, X) hydrolase family members.
Concise_descriptionndx-7 encodes a NUDIX hydrolase; by sequence comparison, NDX-7 is predicted to function as a pyrophosphatase, and is most closely related to the mouse RP2 protein that has unknown substrate specificity but is regulated transcriptionally by the presence of androgens; in C. elegans, loss of ndx-7 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, consistent with the proposed nonessential roles for Nudix proteins in eliminating potentially toxic nucleotide metabolites from cells and modulating levels of metabolic intermediates by shuttling them into alternative biochemical pathways.
Molecular_info (5)
Experimental_info RNAi_result (2)
WB_RNAi_result JA:C43E11.7
MV_SV:mv_C43E11.7
Cenix:159-e1
ReferenceWBPaper00005401
MethodGene