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Gene: F13D12.7   

F13D12.7SMapS_parentSequenceSUPERLINK_CB_II
ChromosomeII
Identity (5)
Gene_info Gene_classgpb
Allele pk13
pk44 Inferred_automatically (2)
Phenotype[C.elegansII] pk13. Tc1 insertion, also excision derivatives pk44: recessive lethal, arrests at L1 stage with very little body wall or pharyngeal muscle activity. In absence of maternal rescue, probably arrests as early embryonic lethal. [NL; JA]
Strain NL344
NL361
GO_term (7)
Structured_description Provisional_descriptiongpb-1 encodes a heterotrimeric G protein beta subunit that is required during embryonic development for the proper orientation of the mitotic spindle during early cell divisions and thus affects the orientation of early cell division axes, and is also required for larval viability, negatively regulates locomotion and egg-laying, and may affect germline development and osmotic balance; expressed in early embryos with highest expression at cell membranes and colocalizes with asters just before and during early cell divisions (this localization is dependent upon G alpha subunits); adults display high levels of expression in neurons with lower expression in the somatic gonad, vulva, and hypodermal seam cells and expression is also detected in the intestine, pharynx, body wall muscles and in the germline. Paper_evidence WBPaper00002525
WBPaper00004576
WBPaper00005878
Person_evidenceWBPerson48
Curator_confirmedWBPerson48
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptiongpb-1 encodes a heterotrimeric G protein beta subunit that is required during embryonic development for the proper orientation of the mitotic spindle during early cell divisions and thus affects the orientation of early cell division axes, and is also required for larval viability, negatively regulates locomotion and egg-laying, and may affect germline development and osmotic balance; expressed in early embryos with highest expression at cell membranes and colocalizes with asters just before and during early cell divisions (this localization is dependent upon G alpha subunits); adults display high levels of expression in neurons with lower expression in the somatic gonad, vulva, and hypodermal seam cells and expression is also detected in the intestine, pharynx, body wall muscles and in the germline.
Molecular_info (6)
Experimental_info (4)
Reference WBPaper00003193
WBPaper00003065
WBPaper00002525
WBPaper00015719
WBPaper00004576
WBPaper00003465
WBPaper00001401
WBPaper00001784
WBPaper00001799
WBPaper00002824
WBPaper00003024
WBPaper00003132
WBPaper00004115
WBPaper00004366
WBPaper00004509
WBPaper00005878
WBPaper00006289
WBPaper00011663
WBPaper00011727
WBPaper00011793
WBPaper00012471
WBPaper00012653
WBPaper00014039
WBPaper00014614
WBPaper00014754
WBPaper00015629
WBPaper00015630
WBPaper00017022
WBPaper00017725
WBPaper00022160
WBPaper00022401
WBPaper00023171
WBPaper00023735
WBPaper00023745
WBPaper00024481
WBPaper00024449
WBPaper00006320
WBPaper00024774
WBPaper00024864
WBPaper00025614
MethodGene