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Gene: F58A4.3   

F58A4.3SMapS_parentSequenceF58A4
ChromosomeIII
Identity Version1
Name (7)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:25WBPerson1971 EventImportedInitial conversion from geneace
StatusLive
Gene_info Gene_classhcp
GO_term (10)
Structured_description Provisional_descriptionThe hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos.Paper_evidenceWBPaper00004736
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptionThe hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos.
Molecular_info Corresponding_CDSF58A4.3
Corresponding_proteinWP:CE00219
KOGKOG1745
Corresponding_PCR_product smd_F54C8.2
smd_F54C8.2:2
sjj_F58A4.3
sjj_F54C8.2
Corresponding_RNAi_reagent (12)
Experimental_info RNAi_result (5)
WB_RNAi_result TH:335f3
[cgc4544]:hcp-3
[cgc4736]:hcp-3
JA:F54C8.2
JA:F58A4.3
[cgc5322]:hcp-3
[cgc5264]:hcp-3
Simmer:F54C8.2
Simmer:F58A4.3
MV_SV:mv_G_YK2579_1
Cenix:322-d11
Cenix:335-f3
Cenix:175-b7
Expr_pattern (5)
Gene_regulation Trans_regulator cgc4735_hcp-1_b
cgc4735_hcp-4
Trans_targetcgc4735_hcp-3
Y2H_targetY2H007532
Reference WBPaper00004544
WBPaper00005322
WBPaper00003702
WBPaper00005142
WBPaper00005173
WBPaper00006142
WBPaper00017716
WBPaper00017717
WBPaper00017877
WBPaper00005178
WBPaper00024319
WBPaper00024405
WBPaper00018629
WBPaper00017715
RemarkSequence connection from [Moore LL, Roth MB]. krb 13/11/01
MethodGene